First human cell based model of genotoxicity published

The TestAVec team is pleased to announce that the peer reviewed research article on hingetox has been published in Nature Gene Therapy. This is the first human cell based model to understand the factors contributing towards genotoxicity.

Here, TestAVec researchers used HIV-1 based lentiviruses, either carrying a native or SIN configuration LTR to infect stem cells and thier differentiated liver cell counterparts. Through a suite of molecular, cell based and bioinformatic assays, we were able to identify a range of factors contributing to genotoxicity. These aid in our understanding of vector saftey by taking vectors back to the drawing board, not just observing immortal cells but understanding the contributory factors. As such, redesign of vectors is paramount to aiding vector saftey with an aim to improving clinical trial success.

If you would like to read the manuscript, the paper is linked here.

Reach out to us if you would like to use hingetox in understanding and de risking the saftey profile of your vectors.